Quarterly report pursuant to Section 13 or 15(d)

Note 4 - Stockholders' Equity (Tables)

v3.19.1
Note 4 - Stockholders' Equity (Tables)
3 Months Ended
Mar. 31, 2019
Notes Tables  
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
    Three Months Ended March 31
      2019       2018  
         
Research and development expenses   $
200,337
    $
64,583
 
General and administrative expenses    
137,629
     
174,252
 
Total   $
337,966
    $
238,835
 
Share-based Payment Arrangement, Option, Activity [Table Text Block]
      Number of Options       Weighted-Average Exercise Price      
Weighted-Average Remaining Contractual
Life (in years)
      Aggregate Intrinsic Value  
                 
Outstanding at January 1, 2019    
1,632,662
    $
10.78
     
5.1
    $
-
 
Granted    
800,000
    $
0.43
     
 
 
Exercised    
-
    $
-
     
 
    $
-
 
Forfeited    
-
    $
-
           
 
 
Outstanding at March 31 2019    
2,432,662
    $
7.37
     
6.4
    $
19,040
 
                                 
Exercisable at March 31, 2019    
1,795,786
    $
9.78
     
5.3
    $
5,712
 
Share-based Payment Arrangement, Option, Exercise Price Range [Table Text Block]
Range of Exercise Prices     Number of Options Outstanding       Weighted-Average Exercise Price      
Weighted-Average Remaining Contractual
Life (in years)
      Aggregate Intrinsic Value  
$0.40
-
$0.50
   
800,000
    $
0.43
     
9.7
    $
19,040
 
$1.00
-
$3.50
   
588,640
    $
1.15
     
7.1
   
-
 
$3.51
-
$13.00
   
532,236
    $
9.76
     
4.1
     
-
 
$13.01
-
$26.00
   
343,782
    $
14.79
     
2.8
     
-
 
$26.01
-
$39.00
   
65,504
    $
30.85
     
2.2
     
-
 
$39.01
-
$56.00
   
102,500
    $
45.03
     
4.3
     
-
 
 
   
2,432,662
    $
7.37
     
6.4
    $
19,040
 
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
      Three Months Ended March 31, 2019
     
Annual dividend    
 
-
 
Expected life (in years)    
5.4
-
5.5 
Risk free interest rate    
2.4%
-
2.5% 
Expected volatility    
 
97%
 
Schedule of Share-based Compensation, Warrant Activity [Table Text Block]
  Range of Exercise Prices       Number of Warrants Outstanding       Range of Expiration Dates  
  $0.30
-
$0.875
     
6,662,709
     
May 2021 - August 2024
 
  $1.11
-
$5.79
     
34,617
     
May 2021 - May 2023
 
  $12.80
-
$12.90
     
39,296
     
January 2022
 
  $16.20
-
$16.30
     
174,544
     
March 2020
 
  $22.10
-
$27.90
     
44,233
     
December 2019 - January 2021
 
  $34.50
-
$39.20
     
236,556
     
October 2019 - October 2021
 
$52.31
     
11,539
       
July 2019
 
 
 
 
     
7,203,494