Annual report pursuant to Section 13 and 15(d)

Note 4 - Stockholders' Equity - Share-based Compensation Expense (Details)

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Note 4 - Stockholders' Equity - Share-based Compensation Expense (Details) - USD ($)
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Share-based compensation expense $ 634,082 $ 1,769,964
Research and Development Expense [Member]    
Share-based compensation expense 133,334 1,091,036
General and Administrative Expense [Member]    
Share-based compensation expense $ 500,748 $ 678,928