Annual report pursuant to Section 13 and 15(d)

Note 4 - Stockholders' Equity (Tables)

v3.19.1
Note 4 - Stockholders' Equity (Tables)
12 Months Ended
Dec. 31, 2018
Notes Tables  
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]
    Year Ended December 31,
    2018   2017
         
Research and development costs   $
133,334
    $
1,091,036
 
General and administrative expenses    
500,748
     
678,928
 
Total   $
634,082
    $
1,769,964
 
Share-based Compensation, Stock Options, Activity [Table Text Block]
    Number of Options   Weighted-
Average
Exercise
Price
  Weighted-
Average
Remaining
Contractual
Life (in years)
  Aggregate
Intrinsic Value
                 
Outstanding at January 1, 2018    
1,894,077
    $
19.76
     
4.7
    $
108,000
 
Granted    
488,640
    $
1.13
     
 
    $
-
 
Exercised    
-
     
-
     
 
     
 
 
Forfeited/Expired    
(750,055
)   $
27.19
     
 
     
 
 
Outstanding at December 31, 2018    
1,632,662
    $
10.78
     
5.1
    $
-
 
                                 
Exercisable at December 31, 2018    
1,166,127
    $
14.59
     
4.4
    $
-
 
Schedule of Share-based Compensation, Shares Authorized under Stock Option Plans, by Exercise Price Range [Table Text Block]
Range of Exercise Prices   Number of Options
Outstanding
  Weighted-
Average
Exercise
Price
  Weighted-
Average
Remaining
Contractual
Life (in years)
  Aggregate
Intrinsic Value
$1.00
-
$3.50
   
588,640
    $
1.15
     
7.3
    $
-
 
$3.51
-
$13.00
   
532,236
    $
9.76
     
4.3
     
-
 
$13.01
-
$26.00
   
343,782
    $
14.79
     
3.1
     
-
 
$26.01
-
$39.00
   
65,504
    $
30.85
     
2.5
     
-
 
$39.01
-
$56.00
   
102,500
    $
45.03
     
4.6
     
-
 
 
   
1,632,662
    $
10.78
     
5.1
    $
-
 
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
    Year Ended December 31,  
      2018       2017  
Annual dividend    
 
-
     
 
-
 
Expected life (in years)    
2.5
-
5.3
     
0.3
-
6.5
 
Risk free interest rate    
2.5%
-
2.8%
     
0.80%
-
2.22%
 
Expected volatility    
97%
-
113%
     
62.2%
-
98.0%
 
Schedule of Share-based Compensation, Warrant Activity [Table Text Block]
Range of Exercise
Prices
    Number of
Warrants
Outstanding
  Range of Expiration Dates
  $0.57
-
$0.875
     
6,162,709
     
May 2021 - August 2024
 
  $1.11
-
$5.79
     
34,617
     
May 2021 - May 2023
 
  $12.80
-
$12.90
     
39,296
     
January 2022
 
  $16.20
-
$16.30
     
174,544
     
March 2020
 
  $22.10
-
$27.90
     
153,755
     
March 2019 - January 2021
 
  $34.50
-
$39.20
     
236,556
     
October 2019 - October 2021
 
  $47.30
-
$52.20
     
275,897
     
January 2019 - July 2019
 
 
 
     
7,077,374
     
 
 
Restricted Stock [Member]  
Notes Tables  
Schedule of Share-based Compensation, Restricted Stock and Restricted Stock Units Activity [Table Text Block]
    Shares of
Restricted
Stock
  Weighted-
Average
Grant Date
Fair Value
         
Outstanding at January 1, 2018    
49,960
    $
3.00
 
Granted    
45,046
    $
1.11
 
Vested    
(72,483
)   $
2.41
 
Forfeited    
-
    $
-
 
Outstanding at December 31, 2018    
22,523
    $
1.11
 
Restricted Stock Units (RSUs) [Member]  
Notes Tables  
Schedule of Share-based Compensation, Restricted Stock Units Award Activity [Table Text Block]
    Number of
RSU's
  Weighted-
Average
Grant Date
Fair Value
         
Outstanding at January 1, 2018    
11,235
    $
11.77
 
Granted    
45,046
    $
1.11
 
Exercised and converted to common shares    
-
    $
-
 
Forfeited    
-
    $
-
 
Outstanding at December 31, 2018    
56,281
    $
3.24
 
                 
Exercisable at December 31, 2018    
33,759
    $
4.66