Quarterly report pursuant to Section 13 or 15(d)

Note 4 - Stockholders' Equity (Tables)

v3.10.0.1
Note 4 - Stockholders' Equity (Tables)
9 Months Ended
Sep. 30, 2018
Notes Tables  
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]
    Three Months Ended September 30,
    2018   2017
         
Research and development expenses   $
22,917
    $
185,492
 
General and administrative expenses    
111,778
     
144,263
 
Total   $
134,695
    $
329,755
 
    Nine Months Ended September 30,
    2018   2017
         
Research and development expenses   $
110,417
    $
993,927
 
General and administrative expenses    
459,856
     
510,216
 
Total   $
570,273
    $
1,504,143
 
Share-based Compensation, Stock Options, Activity [Table Text Block]
    Number of Options   Weighted-
Average
Exercise
Price
  Weighted-
Average
Remaining
Contractual
Life (in years)
  Aggregate
Intrinsic Value
                 
Outstanding at January 1, 2018    
1,894,077
    $
19.76
     
4.7
    $
108,000
 
Granted    
488,640
    $
1.13
     
 
     
 
 
Exercised    
-
    $
-
     
 
    $
-
 
Forfeited    
(550,215
)   $
34.52
     
 
     
 
 
Outstanding at September 30, 2018    
1,832,502
    $
10.37
     
5.6
    $
-
 
                                 
Exercisable at September 30, 2018    
1,300,538
    $
14.08
     
4.9
    $
-
 
Schedule of Share-based Compensation, Shares Authorized under Stock Option Plans, by Exercise Price Range [Table Text Block]
Range of Exercise Prices   Number of Options
Outstanding
  Weighted-
Average
Exercise
Price
  Weighted-
Average
Remaining
Contractual
Life (in years)
  Aggregate
Intrinsic Value
$1.00
-
$3.50
   
638,640
    $
1.15
     
7.7
    $
-
 
$3.51
-
$13.00
   
682,076
    $
9.59
     
5.2
     
-
 
$13.01
-
$26.00
   
343,782
    $
14.79
     
3.3
     
-
 
$26.01
-
$39.00
   
65,504
    $
30.85
     
2.7
     
-
 
$39.01
-
$56.00
   
102,500
    $
45.03
     
4.8
     
-
 
 
   
1,832,502
    $
10.37
     
5.6
    $
-
 
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
      Nine Months Ended September 30,  
      2018       2017  
Annual dividend    
 
-
 
     
 
-
 
 
Expected life (in years)    
 2.5
-
5.3 
     
 0.3
-
5.5 
 
Risk free interest rate    
 2.7%
-
2.8% 
     
 0.8%
-
1.9% 
 
Expected volatility    
 97%
-
117% 
     
 62%
-
83% 
 
Schedule of Share-based Compensation, Warrant Activity [Table Text Block]
Range of Exercise
Prices
  Number of
Warrants
Outstanding
  Range of Expiration Dates
$1.11
-
$5.79
   
3,017,326
   
May 2021 - August 2024
$12.80
-
$12.90
   
39,296
   
January 2022
$16.20
-
$16.30
   
174,544
   
March 2020
$22.10
-
$27.90
   
153,755
   
March 2019 - January 2021
$34.50
-
$39.00
   
5,784
   
October 2019
$39.10
-
$39.20
   
230,772
   
October 2020 - October 2021
$47.30
-
$52.20
   
275,897
   
January 2019 - July 2019
 
   
3,897,374