General form of registration statement for all companies including face-amount certificate companies

Note 4 - Stockholders' Equity (Tables)

v3.19.2
Note 4 - Stockholders' Equity (Tables)
3 Months Ended 12 Months Ended
Mar. 31, 2019
Dec. 31, 2018
Notes Tables    
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
    Three Months Ended March 31
      2019       2018  
         
Research and development expenses   $
200,337
    $
64,583
 
General and administrative expenses    
137,629
     
174,252
 
Total   $
337,966
    $
238,835
 
    Year Ended December 31,
    2018   2017
         
Research and development costs   $
133,334
    $
1,091,036
 
General and administrative expenses    
500,748
     
678,928
 
Total   $
634,082
    $
1,769,964
 
Share-based Payment Arrangement, Option, Activity [Table Text Block]
      Number of Options       Weighted-Average Exercise Price      
Weighted-Average Remaining Contractual
Life (in years)
      Aggregate Intrinsic Value  
                 
Outstanding at January 1, 2019    
81,633
    $
215.60
     
5.1
    $
-
 
Granted    
40,000
    $
8.60
     
 
 
Exercised    
-
    $
-
     
 
    $
-
 
Forfeited    
-
    $
-
           
 
 
Outstanding at March 31 2019    
121,633
    $
147.40
     
6.4
    $
19,040
 
                                 
Exercisable at March 31, 2019    
89,789
    $
195.60
     
5.3
    $
5,712
 
    Number of Options   Weighted-
Average
Exercise
Price
  Weighted-
Average
Remaining
Contractual
Life (in years)
  Aggregate
Intrinsic Value
                 
Outstanding at January 1, 2018    
94,704
    $
395.20
     
4.7
    $
108,000
 
Granted    
24,432
    $
22.60
     
 
    $
-
 
Exercised    
-
     
-
     
 
     
 
 
Forfeited/Expired    
(37,503
)   $
543.80
     
 
     
 
 
Outstanding at December 31, 2018    
81,633
    $
215.60
     
5.1
    $
-
 
                                 
Exercisable at December 31, 2018    
58,306
    $
291.80
     
4.4
    $
-
 
Share-based Payment Arrangement, Option, Exercise Price Range [Table Text Block]
Range of Exercise Prices     Number of Options Outstanding       Weighted-Average Exercise Price      
Weighted-Average Remaining Contractual
Life (in years)
      Aggregate Intrinsic Value  
$8.00
-
$10.00
   
40,000
    $
8.60
     
9.7
    $
19,040
 
$20.00
-
$70.00
   
29,432
    $
23.00
     
7.1
   
-
 
$70.20
-
$260.00
   
26,612
    $
195.20
     
4.1
     
-
 
$260.20
-
$520.00
   
17,189
    $
295.80
     
2.8
     
-
 
$520.20
-
$780.00
   
3,275
    $
617.00
     
2.2
     
-
 
$780.20
-
$1,120.00
   
5,125
    $
900.60
     
4.3
     
-
 
 
   
121,633
    $
147.40
     
6.4
    $
19,040
 
Range of Exercise Prices   Number of Options
Outstanding
  Weighted-
Average
Exercise
Price
  Weighted-
Average
Remaining
Contractual
Life (in years)
  Aggregate
Intrinsic Value
$20.00
-
$70.00
   
29,432
    $
23.00
     
7.3
    $
-
 
$70.20
-
$260.00
   
26,612
    $
195.20
     
4.3
     
-
 
$260.20
-
$520.00
   
17,189
    $
295.80
     
3.1
     
-
 
$520.20
-
$780.00
   
3,275
    $
617.00
     
2.5
     
-
 
$780.20
-
$1,120.00
   
5,125
    $
900.60
     
4.6
     
-
 
 
   
81,633
    $
215.60
     
5.1
    $
-
 
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
      Three Months Ended March 31, 2019
     
Annual dividend    
 
-
 
Expected life (in years)    
5.4
-
5.5 
Risk free interest rate    
2.4%
-
2.5% 
Expected volatility    
 
97%
 
    Year Ended December 31,  
      2018       2017  
Annual dividend    
 
-
     
 
-
 
Expected life (in years)    
2.5
-
5.3
     
0.3
-
6.5
 
Risk free interest rate    
2.5%
-
2.8%
     
0.80%
-
2.22%
 
Expected volatility    
97%
-
113%
     
62.2%
-
98.0%
 
Schedule of Share-based Compensation, Warrant Activity [Table Text Block]
  Range of Exercise Prices       Number of Warrants Outstanding       Range of Expiration Dates  
  $6.00
-
$17.50
     
333,135
     
May 2021 - August 2024
 
  $22.20
-
$115.80
     
1,731
     
May 2021 - May 2023
 
  $256.00
-
$258.00
     
1,965
     
January 2022
 
  $324.00
-
$326.00
     
8,727
     
March 2020
 
  $442.00
-
$558.00
     
2,212
     
December 2019 - January 2021
 
  $690.00
-
$784.00
     
11,828
     
October 2019 - October 2021
 
$1,046.20
     
577
       
July 2019
 
 
 
 
     
360,175
     
 
 
Range of Exercise
Prices
    Number of
Warrants
Outstanding
  Range of Expiration Dates
  $11.40
-
$17.50
     
308,135
     
May 2021 - August 2024
 
  $22.20
-
$115.80
     
1,731
     
May 2021 - May 2023
 
  $256.00
-
$258.00
     
1,965
     
January 2022
 
  $324.00
-
$326.00
     
8,727
     
March 2020
 
  $442.00
-
$558.00
     
7,688
     
March 2019 - January 2021
 
  $690.00
-
$784.00
     
11,828
     
October 2019 - October 2021
 
  $946.00
-
$1,044.00
     
13,795
     
January 2019 - July 2019
 
 
 
     
353,869