Exhibit 99.01

Neuralstem Reports Year End 2017 Fiscal Results and Business Update

- Neuralstem Releases Full Data Set for NSI-189 MDD Trial Showing Patient Rated Outcome and Cognitive Benefits

Nature Medicine Paper Demonstrates Benefit of NSI-566 on Paralysis in Non-Human Primates

GERMANTOWN, Md., April 02, 2018 (GLOBE NEWSWIRE) -- Neuralstem, Inc. (Nasdaq:CUR), a biopharmaceutical company focused on the development of nervous system therapies based on its neural stem cell technology, reported its financial results for the year ended December 31, 2017.

“We remain committed to the development of NSI-566, our lead stem cell therapy candidate, and NSI-189 for major depressive disorder (MDD), which we believe offer novel modalities of treatments for patients that are not effectively treated by current therapies,” said Rich Daly, President & CEO. “We are preparing for the initiation of a clinical trial for NSI-566 in chronic stroke in China and have targeted mid-2018 to begin dosing. The recent findings of NSI-566 that were published in Nature Medicine were very encouraging, demonstrating NSI-566 led to a measurable improvement in forelimb function in injured animals. We look forward to continuing to explore its utility as a potential treatment for paralysis associated with spinal cord injuries.”

“We plan to formulate the clinical development path for NSI-189 in MDD after our meeting with the U.S. Food and Drug Administration which we expect to occur in the second half of 2018. NSI-189 may offer cognitive benefits in addition to antidepressant effects, which would distinguish it from other approved treatments,” Mr. Daly continued.  

Clinical Highlights for Lead Clinical Programs

NSI-566, is a spinal cord-derived neural stem cell line that is being evaluated to treat paralysis associated with stroke, Amyotrophic Lateral Sclerosis (ALS) and chronic spinal cord injury (cSCI).

NSI-189, a benzylpiperazine-aminopyridine, in clinical development for MDD and in preclinical development for Angelman syndrome, irradiation-induced cognitive impairment, Type 1 and Type 2 diabetes, and stroke.

Corporate Highlights

Financial Results for the Year Ended December 31, 2017

Cash Position and Liquidity:  At December 31, 2017, cash and investments was $11.7 million as compared to $20.2 million at December 31, 2016.  The $8.5 million decrease is due to cash used in  operations and $3.8 million to pay down our long-term debt partially offset by $5.4 million of proceeds from the August 2017 public offering of common stock and warrants and $3.2 million of proceeds from the exercise of outstanding warrants.

Operating Loss: Operating loss for the year ended December 31, 2017 was $13.3 million compared to a loss of $20.6 million for the same period of 2016.  The decrease in operating loss for the year was primarily due to ongoing corporate restructuring and cost reduction efforts partially offset by increases in clinical trial expenses as the Company completed the Phase 2 clinical trial of NSI-189.

Net Loss:  Net loss for the year ended December 31, 2017 was $15.7 million, or $1.20 per share (basic), compared to a loss of $21.1 million, or $2.53 per share (basic), on a split adjusted basis for the same period of 2016.  The decrease in net loss was primarily due to a decrease in operating expenses and interest expense due to the maturity of long-term debt in April 2017 partially offset by non-cash expense related to the change in the fair value of our liability classified warrants.

R&D Expenses: The $8.1 million of research and development expenses for 2017 represents a $5.1 million, or 38% decrease over 2016 expenses. This decrease was primarily attributable to a $2.3 million decrease in personnel, facility and other expenses related to ongoing corporate restructuring and cost reduction efforts, a $2.1 million decrease in costs related to our completed NS-189 Phase 2 clinical trial and a $0.7 million decrease in non-cash stock-based compensation expense.

G&A Expenses:  The $5.5 million of general and administrative expenses for 2017 represents a $2.0 million, or 27% decrease over 2016 expenses.  This decrease was primarily attributable to a $1.2 million decrease in payroll and related expenses due to our ongoing corporate restructuring and cost reduction efforts and a $1.0 decrease in non-cash stock-based compensation expense partially coupled.

Liquidity: The Company expects its existing cash, cash equivalents and short-term investments to fund its operations based on our current operating plans, into the second quarter of 2019.

Neuralstem, Inc.
Consolidated Balance Sheets
 December 31,
  2017   2016 
Cash and cash equivalents$  6,674,940  $  15,194,949 
Short-term investments   5,000,000     5,000,000 
Trade and other receivables   312,802     10,491 
Current portion of related party receivable, net of discount   58,784     53,081 
Prepaid expenses   402,273     646,195 
Total current assets   12,448,799     20,904,716 
Property and equipment, net   172,886     269,557 
Patents, net   883,462     990,153 
Related party receivable, net of discount and current portion   365,456     424,240 
Other assets   13,853     15,662 
Total assets$  13,884,456  $  22,604,328 
Accounts payable and accrued expenses $  875,065  $  2,343,936 
Accrued bonuses   418,625     852,963 
Current portion of long-term debt, net of fees and discount   -      3,705,787 
Other current liabilities   220,879     430,738 
Total current liabilities   1,514,569     7,333,424 
Warrant liabilities   3,852,882     3,921,917 
Other long term liabilities   1,876     18,209 
Total liabilities   5,369,327     11,273,550 
Preferred stock, 7,000,000 shares authorized, $0.01 par value; 1,000,000 shares issued and outstanding in both 2017 and 2016   10,000     10,000 
Common stock, $0.01 par value; 300 million shares authorized, 15,160,014 and 11,032,858 shares issued and outstanding in 2017 and 2016, respectively   151,600     110,329 
Additional paid-in capital   217,050,174     204,239,837 
Accumulated other comprehensive income   2,631     3,905 
Accumulated deficit   (208,699,276)    (193,033,293)
Total stockholders' equity   8,515,129     11,330,778 
Total liabilities and stockholders' equity$  13,884,456  $  22,604,328 

Neuralstem, Inc.
Consolidated Statements of Operations and Comprehensive Loss
 Year Ended December 31,
  2017   2016 
Revenues$260,000  $16,246 
Operating expenses:   
Research and development costs 8,096,095   13,155,887 
General and administrative expenses 5,471,010   7,497,202 
Total operating expenses 13,567,105   20,653,089 
Operating loss (13,307,105)  (20,636,843)
Other income (expense):   
Interest income  70,269    58,835 
Interest expense (159,066)  (1,141,297)
Gain on related party settlement   -    458,608 
Gain (loss) from change in fair value of liability classified warrants  (1,470,174)  660,253 
Fees related to issuance of liability classified warrants and other expenses  (799,907)  (474,167)
Total other income (expense)   (2,358,878)  (437,768)
Net loss$(15,665,983) $ (21,074,611)
Net loss per common share - basic and diluted$ (1.20) $ (2.53)
Weighted average common shares outstanding - basic and diluted  13,064,422   8,345,992 
Comprehensive loss:   
Net loss$ (15,665,983) $ (21,074,611)
Foreign currency translation adjustment (1,274)  834 
Comprehensive loss $ (15,667,257) $(21,073,777)

About Neuralstem

Neuralstem is a clinical-stage biopharmaceutical company developing novel treatments for nervous system diseases of high unmet medical need. The Company has two lead development candidates:

Neuralstem’s diversified portfolio of product candidates is based on its proprietary neural stem cell technology.

Cautionary Statement Regarding Forward Looking Information

This news release contains “forward-looking statements” made pursuant to the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements relate to future, not past, events and may often be identified by words such as “expect,” “anticipate,” “intend,” “plan,” “believe,” “seek” or “will.” Forward-looking statements by their nature address matters that are, to different degrees, uncertain. Specific risks and uncertainties that could cause our actual results to differ materially from those expressed in our forward-looking statements include risks inherent in the development and commercialization of potential products, uncertainty of clinical trial results or regulatory approvals or clearances, need for future capital, dependence upon collaborators and maintenance of our intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements. Additional information on potential factors that could affect our results and other risks and uncertainties are detailed from time to time in Neuralstem’s periodic reports, including the Annual Report on Form 10-K for the year ended December 31, 2017 filed with the Securities and Exchange Commission (SEC), and in other reports filed with the SEC. We do not assume any obligation to update any forward-looking statements.


Kimberly Minarovich
Argot Partners (Investor Relations)